New insights into brain Cells signaling based on body cues

Our muscles and brain cells may share more similarities than previously thought. Recent research from the Lippincott-Schwartz Lab reveals a network of subcellular structures, akin to those driving muscle contractions, which also transmits signals in the brain, potentially impacting learning and memory. Jennifer Lippincott-Schwartz, Janelia Senior Group Leader, noted a parallel between brain and muscle function, stating, “Einstein said that when he uses his brain, it is like he is using a muscle, and in that respect, there is some parallel here. The same machinery is operating in both cases but with different readouts”. Endoplasmic Reticulum’s Role The initial link between brain and muscle cells emerged when scientists at Janelia observed unusual activity in the endoplasmic reticulum (ER). The ER consists of membranous sheets and folds inside cells and is vital for various cellular functions. Lorena Benedetti, a research scientist at the Lippincott-Schwartz Lab, noticed molecules tracing a repeating,